It is relatively easy to make solid arguments to the relative effect that life has no meaning. Generally such an argument would explain how everybody is born, and then dies, and how we have no existance outside of that, and thus our life has no significant meaning, as we are just part of "the state of affairs" of the universe.
I say that such arguments are solid, because they are not directly refutable; however, I believe they are (dualistically) sophistic in that they do not recognize the mind-half of dualism.
These arguments rely on the fact that meaning does not exist inherently in the universe; meaning is created by the mind. To evaluate the nature of meaning, we must first evaluate the nature of the mind, which is impossible. It is inexplicable how, out of the corporeal firing neurons in the brain, we get the incorporeal mind. And even if, at some time in the future, specific patterns were to be discovered relating the states of brain and mind, the singular holistic feeling and sense of existance of the mind would still not be able to be explained.
How I feel to be a single being is inexplicable. There is absolutely no logical reason that a single identifiable entity, me, should come out of my brain; and that this entity considers itself to be a single entity, takes responsibility for itself, and still identifies itself as the same entity, though changed, at different times in its existance. There is no way to describe myself other than to state that I exist; in other words, to say, "I am".
And thus, if there is no logical reasoning as to why I exist, yet I exist nonetheless, the same logic can be applied to other things deriving from the mind. That is, any concept deriving from the mind has no logical origin in the universe, since the mind has no logical origin; however, these things, deriving from the mind, still have validity of existance just like the mind does.
So, while physically there is no meaning of life, I exist and I feel there is a meaning of life; and thus, this will be the case for me.